DNA BINDING AND ANTI-MICROBIAL STUDIES OF Ag(II) AND Cu(II) METAL COMPLEXES CONTAINING MIXED LIGANDS OF 1,10- PHENANTHROLINE AND 8-HYDROXYQUINOLINE

The two new complexes Ag(L1) L2(PF6)2[Complex (1) and Cu(L1) L2(PF6)2[Complex (2)] containing bioactive mixed ligand of typeL1=8-Hydroxyquinoline and L2=1,10Phenanthroline have been synthesized and characterized by analytical and spectral methods. The binding constant of the complexes in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2, are 25.79 x 10 Mand 9.95 x 10 Mfor complex (1) and (2) respectively. . The synthesized compounds have been tested against microorganisms such as Gram positive bacteria (Staphylococcus aureus and Proteus vulgaris), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and fungus (Aspergillus niger). A comparative study of the Minimum Inhibitory Concentration(MIC) values of the ligands and their complexes indicates that the complexes exhibit moderate antimicrobial activity than the free ligand and control.